2024 Author: Priscilla Miln | [email protected]. Last modified: 2023-12-16 00:21
Controversial reviews about Fraxiparine during pregnancy are fully justified, since the drug has not passed a full-fledged clinical trial. It is not recommended for use during gestation unless the therapeutic effect outweighs the potential risk.
Thromboembolism is a dangerous pathology leading to blockage of blood vessels, impaired blood flow with further development of ischemia or infarction. The use of Fraxiparine during pregnancy is quite possible, since dysfunction can lead to disability and death.
Importance of proper blood circulation during pregnancy
From the first weeks after conception, the body of a pregnant woman increases the volume of circulating blood. The peak intensity was noted at 31-34 weeks. In the normal state, the amount of the liquid part of the blood increases, since its excessive viscosity is lost, there is no risk of blood clots.
There is a certain percentagewomen with increased blood clotting. Such deviations are possible as a result of hormonal imbalance, decreased activity, or as a result of an infectious disease. It is worth noting that the physiological process in the body itself can provoke hypercoagulability.
Clogs create barriers to oxygen delivery and the transition of pathology to a chronic course is dangerous for the development of the fetus and can adversely affect the nervous system, blood vessels and myocardial function.
The danger of the condition is that blockage of the pulmonary artery usually ends in death.
From the first weeks of pregnancy, a woman should be registered with a leading specialist. Having identified the first signs of a threat, preventive methods of control are prescribed. Diet food, sports and, if necessary, anticoagulant drugs help well.
Who shows the introduction of "Fraxiparine"
According to the instructions, "Fraxiparine" during pregnancy is used as a prophylactic measure to prevent excessive blood clotting, which subsequently contributes to the development of thrombosis. The drug is also indicated for therapeutic use:
- thromboembolism;
- impaired placental blood flow;
- signs of fetal hypoxia;
- angina;
- heart attack (no Q).
It is a frequently prescribed remedy that prevents complications during surgical interventions, orthopedic manipulations. Prevents blood clotting during hemodialysis.
Pregnant women are prescribed the drug with particular caution when the risk of obstetric complications and possible side effects are on the scales. With high blood clotting, when the body does not produce anticoagulants, contrary to negative reviews, Fraxiparine must be administered during pregnancy. Thus, the real threat of intrauterine fetal fading is excluded. Thick blood interferes with the proper fixation of the embryo to the wall of the uterus, the formation of the placenta.
How long can the prescription of the drug
Doctors have no purpose to harm the patient. Gynecologists are convinced that Fraxiparin does not harm the mother and unborn child, but not in the early stages. The appointment of the drug is excluded in the first trimester, as it can provoke a miscarriage. In the second trimester, the drug is prescribed by a leading specialist under supervision, if the test results indicate high clotting.
Composition of Fraxiparine in injections
The active substance of Fraxiparine is calcium nadroparin. The auxiliary components are calcium hydroxide or dilute hydrochloric acid.
The product is endowed with a powerful antithrombotic effect and emergency long-term activity.
The introduction of the solution leads to the absorption of the active substance by 88%. The maximum plasma saturation was recorded after 3-4 hours. It has the ability to be metabolized in the liver, excreted from the body per day. The active effect of the druglasts up to 18 hours.
It should be noted that pregnant women with kidney failure do not prescribe the drug, as in this case it accumulates in the kidneys. If the doctor decides to continue therapy, the dosage should be reduced.
Issue form
The drug is produced in the form of a solution for injection. Packaged in disposable syringes with a dosage of 0.3/2850 IU; 0.4/3800 IU; 0.6/5700 IU; 0.8/7600 IU ml. The volume of Fraxiparine injected into the abdomen during pregnancy is determined by the leading specialist. The amount of the substance is affected by the weight of the patient, the presence of contraindications, concomitant pathologies, the general condition of the woman. The duration of the course of therapy is also calculated by the doctor. Sometimes injections are shown throughout the entire gestation period, but we can conclude from numerous reviews that Fraxiparine is canceled at 36-37 weeks of gestation. Further monitoring of the expectant mother is carried out in a hospital.
What is the drug
Dysfunction of blood vessels, violation of the integrity of warm-blooded animals, leads to the activation of barrier functions. Thrombocin begins to be intensively synthesized, making the blood more viscous. Due to the gluing of cells, a clot is formed that blocks the ducts. Continuous production of thrombocin develops thrombocytosis - the formation of blood clots in intact vessels.
Injection solution - anticoagulant. Its action is aimed at stopping the processes of thrombosis. The main active ingredient is fraxeparin-nadroparin calcium. After the introductionthe drug reacts with proteins, thinning the blood plasma.
Violation of blood circulation leads to a lack of proper nutrition and oxygen supply to organs and tissues, the fetus also suffers from hypoxia. Subsequently, such a development of events is fraught with spontaneous abortion.
How to properly inject
There is another form of release - tablets, but they are not prescribed to pregnant women in order to exclude the effect on the digestive system and liver function. The injections are sterile and can be administered subcutaneously or intravenously. During the period of gestation, doctors use the subcutaneous method and reviews of Fraxiparine during pregnancy are not very good, since the procedure is painful. Sometimes it is precisely the fact that injections are made in the stomach that scares the patients the most, bruises and bumps remain. The course of therapy is long, often women continue treatment at home, so you need to know how to inject Fraxiparine during pregnancy.
Algorithm of actions:
- the syringe is taken with the needle up, air is released until a droplet appears at the end of the needle;
- the injection site is treated with a cotton swab dipped in alcohol (midline of the abdomen, 2 fingers below the navel);
- grab the skin fold with fingers vertically;
- a needle is inserted into the upper part of the fold, perpendicular to the surface of the skin;
- the solution is administered smoothly, slowly;
- after the needle is removed, cotton soaked in alcohol is applied to the puncture site.
Do not rub the area of skin after the injection. Also don't be active.quarter of an hour. The recommended dose for the administration of Fraxiparine during pregnancy is 0.3 mg.
Features of the action of injections during pregnancy
Women's body changes as the pregnancy progresses. Along with the volume, the number of blood vessels and capillaries increases. Blood stasis leads to the development of pathological processes and chronic respiratory failure of the fetus. It is also necessary to understand that in the later stages, compression of the veins of the small pelvis by the uterus is inevitable, which leads to a violation of the outflow of blood from the veins of the legs. As the reviews confirm, "Fraksiparin" during pregnancy is an effective drug to prevent the formation of blood clots. It is important to exclude thrombosis of the lower extremities so as not to provoke the development of pulmonary embolism. If you delve into the instructions, Fraxiparine during pregnancy does not pose a danger, but its use is indicated only in case of urgent need.
Are injections dangerous during pregnancy
Today, "Fraxiparine", according to doctors, is considered an effective means of preventing and treating thrombosis. The very fact that the substance is injected into the stomach is frightening for some, but you should not panic. It is necessary to trust the actions of a specialist. The solution is injected into the umbilical zone, but this does not harm the fetus and does not affect the course of pregnancy. Increased blood clotting is more dangerous, therefore, it is worth discarding doubts and directing energy to restore vascular conductivity - this is how you take care of your mother and baby.
Experienced doctors reject stereotypes and negative reviews about Fraxiparine whenpregnancy, as the drug eliminates the threat of spontaneous abortion and treats blood clots, regardless of the complexity of the case.
Contraindications during pregnancy
Before prescribing a therapeutic regimen, the doctor must correctly assess the situation. If the benefit to the mother is greater than the expected harm to the fetus, only contraindications can be prohibited.
When pregnant, the reason for refusing treatment may be:
- individual immunity to the active substance;
- deficiency of clotting factors, bleeding (coagulopathy);
- thrombocytopenia;
- organic organ damage;
- head, back, eye injuries;
- ineffectiveness of antiplatelet agents.
Treatment is carried out under the supervision of a leading specialist. Pay attention to the possible manifestations of side effects in the form of a rash, itching, urticaria. A more serious reaction requiring emergency intervention is Quincke's edema, anaphylactic shock. Exceeding volumes can provoke bleeding. Even the minimum dosage, judging by the reviews - 0.3 Fraxiparine during pregnancy requires the supervision of specialists.
Patients with impaired renal function, with severe renal failure, do not use this drug. The doctor selects analogues less detrimental to the functioning of the organs. In mild to moderate form, the course can be supervised by a specialist, but with a reduced dosage, to prevent the developmentthromboembolism.
Use drug with caution
"Fraxiparine" can be prescribed at a high risk of bleeding, under medical supervision in case of:
- liver failure;
- kidney failure;
- hypertension;
- peptic ulcers;
- failures in blood circulation in the shell and retina of the eye;
- necessary therapy for more than a decade;
- combinations with drugs that increase the likelihood of bleeding.
Who is at risk
The gynecologist examines the patient's medical history in detail. In the event that a pregnant woman previously had non-developing pregnancies, inability to bear a fetus, phlebological diseases, a course of therapy with Fraxiparine will most likely be prescribed.
Special Instructions
Before using any drug belonging to the class of low molecular weight heparins, you must carefully study the instructions. Pay special attention to dosage units.
Also important to consider:
- alternation of low molecular weight heparin drugs is unacceptable;
- the drug of the same name with the prefix "Forte" requires a revision of the dosage;
- grading on syringes is necessary to select the dose according to weight;
- the drug is not administered intramuscularly;
- in the course of therapeutic actions, clinical monitoring of changes in platelet concentration is carried out.
In rare cases, with arterialor venous thrombosis, thrombocytopenia occurs, which should be considered when:
- thrombocytopenia;
- low platelets;
- with negative dynamics of diagnosed thrombosis;
- DIC.
The above cases are a reason to interrupt treatment.
If the question arises about the ability to drive a car, then there is no data on the effect of Fraxiparine on the ability of a pregnant woman to cope with mechanisms.
When buying a drug, pay attention to the expiration date, the integrity of the package. To avoid falsification or making a deal with unscrupulous sellers, it is recommended to purchase an injection solution in pharmacies or trusted online stores.
The storage temperature of the drug should not freeze the solution. Also, the thermometer can not rise above +30. A drug from list B is stored in places inaccessible to children.
Drug compatibility
To prevent the development of hyperkalemia, Fraxiparine is not used simultaneously with potassium-sparing diuretics, potassium s alts, ACE inhibitors, Cyclosporine, Tacrolimus.
It must be taken into account that non-steroidal PVP and Aspirin, indirect anticoagulants enhance each other's action.
Concomitant use of antiplatelet agents may cause bleeding.
Analogues
If for some reason it was not possible to purchase Fraxiparine, its structural analogue in terms of the active substance isFraxiparine Forte.
If the patient is diagnosed with individual resistance to the drug or there are other contraindications to Fraxiparine, the doctor may prescribe a drug from the same pharmacological group with a different active ingredient in the structure:
- Agioks, Angioflux, Anfibra, Arixtra.
- Warfarex, Viathromb, Warfarin.
- Calciparin, Clexane, Xarelto.
- Lavenum, Lyoton, Marevan.
- "Pelentan", "Piyavit", "Pradaksa".
- Seprotin, Sinkumar.
- "Trombofob", "Trombless", "Troparin".
- Cibor, Fragmin, Fenilin.
- Eliquis, Emeran, Exanta.
An analogue is selected by the attending physician, taking into account all the features of a particular case.
Conclusion
Whether it is advisable to prescribe low molecular weight heparins during the period of gestation - the question remains open. It must be taken into account that the instructions were drawn up several decades ago, and tests capable of guaranteeing safety were not carried out. However, there are women in dire need of anticoagulant treatment. You should not focus on reviews on the use of Fraxiparine during pregnancy. Only a doctor, taking into account all the nuances (the patient's condition, comorbidities, term) can determine the need for the use of the drug Fraxiparine.
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