Is it possible to take "Amoxiclav" during pregnancy: instructions, reviews

2024 Author: Priscilla Miln | [email protected]. Last modified: 2023-12-16 00:21

For a future mother, it is very important to keep the baby he althy and exclude possible complications during pregnancy. Among the risks in the first place are infectious diseases, the treatment of which is not complete without the use of medicines.

It's good when a woman avoids medication during pregnancy. But unfortunately, this happens very rarely. Few people can resist the attack of microorganisms that cause disease. Moreover, against the background of pregnancy, the immune system weakens.

Any infection during pregnancy must be carefully and carefully treated in order to eliminate the risk of infection of the fetus, which threatens the development of serious complications, up to the appearance of an incurable sore in the baby.

Sometimes, in the fight against inflammation, you have to use "heavy artillery" in the form of antibiotics. Often expectant mothers worry about the safety of the child to the point that they refusereceiving the above funds. This is not a very smart approach, as ignoring the antibiotic can complicate the situation even more.

No self-respecting doctor would prescribe a drug to a pregnant woman that could harm her baby. There are drugs that have been clinically and laboratory tested to be relatively safe. The list of such drugs includes "Amoxiclav". During pregnancy, doctors often prescribe it.

Antibiotic action

Amoxiclav is a modern antibiotic of the penicillin group. It is well absorbed in the gastrointestinal tract, penetrates into the blood and spreads throughout the body. Excreted by the kidneys. The antibiotic does not penetrate the central nervous system, but easily passes through the placental barrier.

The active substance of the drug is amoxicillin in combination with clavulanic acid, making it much more effective than pure amoxicillin. Pathogenic microorganisms in the course of their life secrete a special enzyme that destroys the medicine. Because of this, amoxicillin is useless for streptococci, staphylococci, echinococci, pathogens of brucellosis and salmonellosis, etc. Clavulanic acid, which is part of the drug, makes amoxicillin more resistant to the enzyme, which contributes to a more successful fight against bacteria that provoke the disease.

Can I use it during pregnancy?

The manufacturers of the antibiotic mention in the instructions that it does not cause a violation of embryonic development, and therefore is allowed during the period of an "interesting" situation. But despite the fact that "Amoxiclav"safe during an "interesting" situation, it should be prescribed only after a thorough analysis of the clinical picture and a comparison of the possible risk with the intended benefit of the drug.

The main condition for the safety of Amoxiclav during pregnancy is to take it strictly according to the doctor's prescription and in the recommended dosages.

1st trimester antibiotic use

In America, studies of this drug have been conducted more than once, in which pregnant women at different gestational ages participated. As a result, very positive data were obtained, which proved the high safety of the drug compared to analogues.

However, in a sample of early gestational women, a number of antibiotic-related complications were identified in newborns. There have been cases of ruptured membranes in pregnant women and necrotizing enterocolitis in infants. Therefore, during pregnancy, treatment with Amoxiclav in the 1st trimester is highly undesirable.

The use of "Amoxiclav" in the 2nd trimester

This period is most favorable for antibiotic therapy. The fetus is almost formed, and the components of the drug are no longer so dangerous for him. However, the risk of complications due to taking Amoxiclav during pregnancy in the 2nd trimester still remains.

In Israel, laboratory tests were conducted, in which women took part at a gestational age of 3-4 months, who were treated for ENT infections. The patients were divided into two groups: the first group took "Amoxiclav", the second - "Amoxicillin". As a result 98%women who took Amoxiclav gave birth to he althy children. In relation to the remaining 2%, various violations were identified. In the second group, much more childhood pathologies were recorded.

"Amoxiclav" in the 3rd trimester

Many obstetricians believe that taking this antibiotic in late pregnancy is safe for the baby. However, when taking "Amoxiclav" in the 3rd trimester of pregnancy, women often have problems with digestion, the development of pathogenic bacteria in the intestines, and allergic reactions become more pronounced.

Important! The components that make up the antibiotic cross the placenta in small doses, so it is advisable to take Amoxiclav with low doses of amoxicillin, for example, 375 ml or 625 ml.

"Amoxiclav" - instructions for pregnancy

Before you start taking "Amoxiclav" during the gestation period, you should study the instructions up and down. Especially pay attention to the point of compatibility with other drugs.

• Do not use the drug along with another antibiotic or antimicrobial agent. This tandem will reduce the effectiveness of Amoxiclav.
• Combining an antibiotic and allopurinol can cause a severe allergic reaction.
• "Amoxiclav" enhances the toxic effect of methotrexate.
• An antibiotic is contraindicated if the pregnant woman is already being treated with disulfiram or sulfasalazine.

Compliance with drug compatibility rules will reduce the riskside effects during pregnancy.

Pregnancy Dosage

The dosage of the medicine for women in position is calculated individually, depending on the severity of the disease and the degree of damage, as well as the individual characteristics of the organism. It is strictly forbidden to change the dosage prescribed by the doctor.

"Amoxiclav" is available in three forms:

1. Amoxicillin tablets - 250, 500 and 875 mg with an additional unchanged 125 mg of clavulanic acid.
2. Powder for oral suspension.
3. Powder for intravenous injection.

Help! The drug in liquid form is suitable for the treatment of children. For adults, including pregnant women, doctors most often prescribe pills.

"Amoxiclav" during pregnancy should be taken twice a day, one tablet of 625 mg or three times (every 8 hours), but one tablet of 375 mg. The drug is recommended to be dissolved in 100 ml of pure water and taken with meals. The course of treatment is 5-7 days.

Important! When prescribing "Amoxiclav" during pregnancy, the existing pathologies and diagnoses should be taken into account. In case of impaired renal function, it is necessary to change the dosage (downward) and increase the time interval between taking the tablets.

Indications for antibiotic therapy

"Amoxiclav" during pregnancy is prescribed for the treatment of infectious diseases caused by microorganisms sensitive to its components:

• acute and chronic bronchitis, sinusitis, pneumonia,otitis media, laryngitis;
• lesion of the urogenital system;
• gynecological infections (exceptions are mycoplasmosis and chlamydia);
• urinary tract infection;
• prevention and treatment of complications in the postoperative period;
• infections of bone tissue and joints, including osteomyelitis;
• odontogenic inflammatory processes, including periodontitis.

Side effects

In most cases, Amoxiclav is well tolerated during pregnancy, rarely when there are side effects such as:

• nausea, bouts of vomiting;
• diarrhea;
• headache;
• dizziness;
• convulsive syndrome;
• anaphylactic shock;
• Quincke's edema;
• skin rash along with itching and redness;
• colitis.

Many symptoms appear on the background of taking high doses of amoxicillin and are reversible. In order to reduce discomfort from the gastrointestinal tract, the drug should be taken with meals. If any allergic reactions occur, stop taking Amoxiclav and call an ambulance.

Contraindications

There are very few contraindications for Amoxiclav during pregnancy, which is why it has become the drug that is recommended for women to treat infections during an “interesting” situation. The antibiotic is prohibited for admission in the presence of the following pathologies:

• hypersensitivity to the composition of the drug;
• intolerance to penicillin antibiotics;
• severe disorders of the kidneys and (or) liver;
• lymphocytic leukemia;
• mononucleosis.

Should be taken with caution in severe allergies and asthma. In this case, before therapy, the patient's reaction to the penicillin series is checked. If there is intolerance to one or more components, an alternative method of treatment is selected.

Important! Ignoring a hypersensitivity test threatens to cause fatal anaphylactic shock.

"Amoxiclav" during lactation is prescribed in very rare cases. The components of the composition easily penetrate into mother's milk and can cause a number of undesirable symptoms in the baby, for example, bloating, diarrhea, candidiasis. Therefore, for the duration of treatment, it is worth stopping breastfeeding or replacing Amoxiclav with another drug similar in its effect.

Analogues

In addition to "Amoxiclav", there are other antimicrobial drugs that are approved for use during pregnancy. However, it is not worth making an independent decision about replacing one drug with another.

Analogues of "Amoxiclav" in composition and action are the following medicines:

• Augmentin;
• "Clavamitin";
• Flemoxin Solutab.

Reviews

Pregnant women are afraid to take antibiotics because of their fears and doubts. In this connection, they are often interested: is it possible to "Amoxiclav" during pregnancy?The experience of mothers who have already faced a similar choice will help clarify the situation. Many of those who were treated with Amoxiclav during pregnancy noted weakness, dizziness, nausea and loss of appetite. But this was only a temporary phenomenon, and soon he alth was restored, and the test results returned to normal.

Approximately in 5% of cases, after the use of "Amoxiclav" in the early stages of pregnancy, allergic reactions and symptoms of hypersensitivity to the drug were observed. In such situations, the drug was replaced with another antimicrobial agent.

It is important to remember that each organism is individual and reacts to the medication in its own way, so first of all you need to listen to the opinion of specialists and the state of your body.

Conclusion

Although "Amoxiclav" is possible during pregnancy due to the fact that it is considered a relatively safe remedy, it is still not the drug that should be consulted at the first ailments. The decision to prescribe it is made in case of emergency, when there is a risk of infection of the fetus or a threat to the he alth of the mother.