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"Flemoklav Solutab" during pregnancy: indications for use, dosage, reviews
"Flemoklav Solutab" during pregnancy: indications for use, dosage, reviews
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"Flemoclav Solutab" is an antimicrobial drug with a wide area of ​​effect. The medicine helps to cope with colds, sore throats and pharyngitis. Well tolerated by patients. It is considered one of the safest antibiotics. "Flemoklav Solutab" during pregnancy is also allowed to be used. Studies have shown that this medication does not harm the fetus and does not adversely affect the condition of a pregnant woman.

"Flemoklav Solutab": the composition of the drug

This medicine is only available in tablets. Pills are oblong white with a slight yellowish tint. They are produced in various concentrations. May be present in the preparation "Flemoklav Solutab" 125 mg of amoxicillin and 31.25 mg of clavulanic acid (clavulanic acid). Tablets are produced containing 250, 500 mg of amoxicillin and 62, 5, 125 mg of clavulanate, respectively. The mosta large concentration of active ingredients is in the drug "Flemoklav Solutab" 875/125 (during pregnancy, this form of release is rarely prescribed by a doctor), where 875 mg of amoxicillin and 125 mg of clavulanic acid.

The secondary components of the tablets are microcrystalline cellulose, vanillin, magnesium stearate, crospovidone, saccharin, apricot fragrance. Tablets are packed in aluminum blisters of 4 or 7 pieces. The package can contain from 14 to 20 tablets.

The drug is dispensed from pharmacies without a doctor's prescription. The shelf life of the medicinal product is three years from the date of its manufacture. The medication should be kept in a dry and cool place, securely protected from children, at temperatures up to +25˚С.

Pharmacological action of the drug

"Flemoklav Solutab" during pregnancy is prescribed quite often. This is the most gentle antibiotic of the penicillin series. Refers to beta-lactamase inhibitors. The drug is combined and contains two active ingredients. These are amoxicillin and clavulanate. Many patients are interested in the question: "Amoxicillin is an antibiotic or not?" The answer to it is unequivocal. Amoxicillin is an antibiotic and is often used to treat respiratory, viral, and infectious diseases.

This drug has a bactericidal effect on the body. It inhibits the walls of bacteria. It shows its activity against both gram-negative and gram-positive microorganisms. This includes strains that produce beta-lactamase. The antibiotic contains clavulanic acid.acid. Why is this component present in antibiotics? First of all, clavulanic acid inhibits types II, III, IV and V of beta-lactamases, but does not show its activity against type I beta-lactamases. Successfully shows its effect in combination with penicillins. This combination prevents the degradation of amoxicillin under the influence of beta-lactamases. Significantly expands the area of ​​effect of the drug.

Flemoklav solutab during pregnancy

The bioavailability of amoxicillin is 94%. The absorption of the active substance is not affected by food intake. The highest concentration of amoxicillin in plasma is observed after a couple of hours. After a single use of a tablet with a dosage of 500/125 mg, after eight hours, the average concentration of amoxicillin is 0.3 mg / l. This component interacts with proteins by 17–20%. Has the ability to cross the placenta. Small amounts are found in breast milk.

Amoxicillin is 10% metabolized in the hepatic organ. About 50% of the drug is excreted by the kidneys. The rest of the drug is excreted in the bile. The elimination half-life in patients without kidney and liver problems is six hours. If the patient suffers from anuria, then the half-life increases to 10-12 hours. The drug may be excreted during hemodialysis.

Bioavailability of clavulanate is 60%. The absorption process is not affected by food intake. The highest concentration of this active substance in the blood is observed two hours afterthe use of tablets. If you take the tablet "Flemoklav Solutab" 125/500 mg (clavulanate / amoxicillin), then after eight hours the highest concentration of clavulanic acid will be 0.08 mg / l. Clavulanate is 22% bound to blood proteins. It freely penetrates the placental barrier. Data on the penetration of this substance into breast milk are not available.

Clavulanic acid is metabolized by 50–70% in the hepatic organ. About 40% of this substance is excreted by the kidneys. Half-life - 60 minutes.

Indications for the use of tablets

"Flemoklav Solutab" during pregnancy can be prescribed to patients in case of emergency. Indications for the use of this medication are diseases of an infectious and inflammatory nature, pathologies of the upper respiratory tract, diseases of the ENT organs, among them - sinusitis, pharyngitis, otitis media, tonsillitis. The drug is prescribed for pathologies of the lower respiratory tract, when diagnosed with bronchitis or community-acquired pneumonia. Moreover, the drug is taken both in the acute and in the chronic stage of the development of the disease. The drug is prescribed for infectious diseases of the skin and soft tissues, diseases of the genitourinary system and the renal organ.

With extreme caution, tablets are prescribed for renal and hepatic insufficiency. With pathologies of the gastrointestinal apparatus, including when there is a history of colitis.

Application

Flemoklav Solutab 125

"Flemoklav Solutab" during pregnancy is prescribed when antibiotic therapy is vitalwoman, and more gentle drugs do not help. In other words, as a last resort. As a result of numerous studies, it was found that the drug does not have a pathogenic effect on the development of the fetus and on the condition of the newborn child. The use of these tablets in the II and III trimester is considered safe. "Flemoklav Solutab" during pregnancy in the 1st trimester is prescribed with extreme caution.

This drug is approved for use during lactation. Despite the fact that amoxicillin passes into breast milk, it does not have a negative effect on the child. The combination of a combination of substances such as amoxicillin and clavulanic acid does not adversely affect the baby.

Contraindications

Flemoclav Solutab is not prescribed for hypersensitivity to the components that appear in the composition of the drug. Do not prescribe medication for hypersensitivity to beta-lactam antibiotics, cephalosporin drugs and hypersensitivity to penicillins.

Amoxicillin is an antibiotic or not

Contraindication to the use of the drug is dysfunction of the hepatic organ, jaundice, which at the time of taking "Flemoclav Solutaba" are in history. In patients diagnosed with lymphocytic leukemia and infectious mononucleosis, the likelihood of exanthema increases. Because of this, the combination of amoxicillin with clavulanate should not be prescribed for these conditions.

"Flemoklav Solutab": instructions for use during pregnancy

In order for the treatment of "FlemoklavSolutab "to exclude dyspeptic symptoms, you need to take the pills at the very beginning of the meal. The pill should be swallowed whole with water. If the tablet is hard to swallow, then you can dissolve it in 100 g of water and drink the resulting solution.

The duration of treatment is affected by the severity of the disease. The course of therapy should not exceed 14 days.

Pregnant women, adults and children weighing over 40 kg are prescribed 500 mg/125 mg three times a day. If the disease is severe, has become chronic or is accompanied by complications, then the dosage is doubled.

Why is clavulanic acid used in antibiotics?

The dosage of "Flemoklava Solutab" during pregnancy should not exceed the recommended above. The use of the drug in the II and III trimesters is made after assessing the benefits of the drug for the mother and the possible risk to the child. Pregnant women should avoid taking tablets with a dosage of active ingredients 875 mg / 125 mg. Pills with a concentration of active ingredients 125 mg / 31.25 mg, 250 mg / 62.5 mg, 500 mg / 125 mg can be used in all trimesters of pregnancy. In the first trimester, these tablets are taken with extreme caution.

Children from two to twelve years old, whose weight ranges from 13-37 kg, are prescribed a daily dosage of amoxicillin in the amount of 20-30 mg and clavulanate at a dose of 5-7.5 mg. This amount of the drug is calculated per 1 kg of body weight of the child. As a general rule, ages 2-7 years old are given one tablet of 125/31, 25mg three times a day.

Bage category from seven to twelve years, the drug is prescribed one pill 250/62, 5 mg three times a day. If there are severe infectious diseases, then the dosage is doubled. The maximum possible dose for a child is 60 mg of amoxicillin and 15 mg of clavulanate, calculated per 1 kg of weight.

Children from three months to two years old weighing 5–12 kg are prescribed 20–30 mg of amoxicillin and 5–7.5 mg of clavulanate per kilogram of baby's weight. This is usually a dose of 125/31.25 to be taken twice a day.

In patients suffering from renal insufficiency, the excretion of this drug is delayed, so their treatment is as follows:

If the GFR (glomerular filtration rate) is 10–30 ml/min, then the dosage of amoxicillin for adults is 500 mg twice a day, for children - 15 mg/kg taken twice a day.

GFR over 10 ml/min. the dose of amoxicillin for adults is 500 mg per day, for children - 15 mg / kg per day.

For adults on hemodialysis, amoxicillin 500mg daily, 500mg during dialysis, and 500mg after dialysis.

Patients with impaired functioning of the hepatic organ, the drug is prescribed with extreme caution. When taking Flemoclav Solutab, these patients should be under the control of a doctor who carefully monitors the work of the liver.

Side effects

Flemoclav solutab

Indications for the use of "Flemoklav Solutab" during pregnancy are exactly the same as for other people. When this drug is taken by pregnant women, adults, andchildren sometimes experience negative reactions of the body.

This is primarily an allergy, which manifests itself in the form of urticaria, erythematous rashes, dermatitis, Stevens-Johnson syndrome. In isolated cases, a burrow-like exanthema may appear. These reactions of the body depend on the condition of the patient, the severity of the disease and the prescribed dosage.

When taking Flemoklav Solutab tablets, negative reactions of the digestive system are possible. They manifest themselves in the form of nausea, gag reflex, diseases of the hepatic organ, increased activity of "liver" transaminases. Rarely enough, cholestatic jaundice, colitis and hepatitis occur when taking this drug.

When taking the drug, there is an increase in alkaline phosphatase, transaminase (ACT and ALT), bilirubin in men and the elderly over 65.

Among other adverse reactions of the body, candidiasis, an increase in prothrombin time and progression were observed.

Overdose of this medication may cause vomiting, diarrhea, nausea and other gastrointestinal disturbances. Possible violation of electrolyte and water metabolism.

If overdose symptoms occur, activated charcoal is prescribed. If convulsions occur, diazepam is prescribed. The occurrence of other negative reactions is treated symptomatically. If kidney failure occurs, then hemodialysis is performed.

General instructions

Flemoklav solutab composition of the drug

Many patients, seeing the composition of Flemoklav Solutab, ask themselves:"Amoxicillin is an antibiotic or not?" Yes, this drug, like the active ingredient amoxicillin, is an antibiotic belonging to the penicillin series.

In patients with hypersensitivity to the components of this drug, an anaphylactic reaction may occur. Therapy in this case should be urgently canceled and the patient should be prescribed a more appropriate treatment. To eliminate anaphylactic shock, an injection of adrenaline and corticosteroids is urgently needed.

There is a possibility of hypersensitivity and cross-resistance to cephalosporins and other penicillins. As with the use of other antibiotics, when taking Flemoclav Solutab, bacterial and fungal infections, including candidiasis, may occur. When superinfections appear, the drug is canceled, and the treatment is reviewed.

In rare cases, there is an increase in prothrombin time. "Flemoklav Solutab" is prescribed with caution to patients who are undergoing anticoagulation treatment.

Non-enzymatic methods for determining the amount of sugar in the urine, as well as testing for urobilinogen, can give a false positive result.

"Flemoklav Solutab" contains clavulanic acid. It shows little activity against enterococci and Pseudomonas aeruginosa. Moderately affects Haemophilus influenzae and Enterobacteriaceae. To a greater extent, the drug is active against bacteroids, streptococci, moraxella and staphylococci. The beta-lactam compound is effective against legionella and chlamydia. That's what clavulanic antibiotics are foracid is present. It expands their reach and enhances their effectiveness.

Cost

Flemoklav solutab during pregnancy reviews

The drug "Flemoklav Solutab" can be purchased without problems at any pharmacy. It is released without a doctor's prescription. It costs within 400 rubles for 20 tablets. The price, depending on the markup at the outlet, may vary slightly.

Reviews of pregnant women

Reviews about "Flemoclav Solutab" during pregnancy are mostly positive. Women note that during treatment they did not experience any adverse reactions. The drug was well tolerated. He helped many ladies in the position to cure purulent tonsillitis, prolonged cough, cystitis. Often prescribed for influenza, SARS and sinusitis. In all of the above cases, he showed himself only on the positive side and did not cause negative phenomena.

The only drawback for women is the size of the pills. According to them, with angina it is difficult to drink them. For this reason, many ladies diluted the drug in water and took the medicine in liquid form.

In all cases, when the drug was prescribed to pregnant women, he perfectly coped with the task and did not cause any complaints from patients.

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